Protein Details: 5-hydroxytryptamine receptor 3B

Protein ID

ICDB_Pro_0294

Protein Name

5-hydroxytryptamine receptor 3B

Gene Name

HTR3B

Organism

Homo sapiens (Human)

Length

441 amino acids

AlphaFoldDB

AF-O95264-F1-model_v4.pdb

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes;which when activated cause fast;depolarizing responses in neurons.

Sequence

MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Motion Sickness and Brain Small Vessel Disease 3

Location

Expressed in the brain cortex;in the caudate nucleus;the hippocampus;the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen;small and large intestine;uterus;prostate;ovary and placenta.

DOI ID

10.1074/jbc.274.43.30799; 10.1038/16941; 10.1016/j.gene.2006.08.002; 10.1038/ng1285; 10.1038/nature01788; 10.1124/mol.106.032144; 10.1111/j.1471-4159.2010.07129.x; 10.1002/ajmg.b.30070; 10.1007/s10067-004-0927-2; 10.1016/j.biopsych.2005.11.008; 10.1038/nature09629

RefSeq

NP_006019.1 [O95264-1]; XP_011541365.1